Sunday 2 July 2017



Primary and Secondary research

http://www.nhs.uk/conditions/cancer/pages/introduction.aspx

Bone tumors may be classified as "primary tumors", which originate in bone or from bone-derived cells and tissues, and "secondary tumors" which originate in other sites and spread (metastasize) to the skeleton. Carcinomas of the prostate, breasts, lungs, thyroid, and kidneys are the carcinomas that most commonly metastasize to bone. Secondary malignant bone tumors are estimated to be 50 to 100 times as common as primary bone cancers.
Primary bone tumors

Primary tumors of bone can be divided into benign tumors and cancers. Common benign bone tumors may be neoplastic, developmental, traumatic, infectious, or inflammatory in etiology. Some benign tumors are not true neoplasms, but rather, represent hamartomas, namely the osteochondroma. The most common locations for many primary tumors, both benign and malignant include the distal femur and proximal tibia (around the knee joint).

Examples of benign bone tumors include osteoma, osteoid osteoma, osteochondroma, osteoblastoma, enchondroma, giant cell tumor of bone, aneurysmal bone cyst, and fibrous dysplasia of bone.

Malignant primary bone tumors include osteosarcoma, chondrosarcoma, Ewing's sarcoma, fibrosarcoma, and other types.

While malignant fibrous histiocytoma (MFH) - now generally called "pleomorphic undifferentiated sarcoma" - primary in bone is known to occur occasionally, current paradigms tend to consider MFH a "wastebasket" diagnosis, and the current trend is toward using specialized studies (i.e. genetic and immunohistochemical tests) to classify these undifferentiated tumors into other tumor classes. Multiple myeloma is a hematologic cancer, originating in the bone marrow, which also frequently presents as one or more bone lesions.

Germ cell tumors, including teratoma, often present and originate in the midline of the sacrum, coccyx, or both. These sacrococcygeal teratomas are often relatively amenable to treatment.

https://en.wikipedia.org/wiki/Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Not all tumors are cancerous; benign tumors do not spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss and a change in bowel movements. While these symptoms may indicate cancer, they may have other causes. Over 100 types of cancers affect humans.


Tobacco use is the cause of about 22% of cancer deaths. Another 10% is due to obesity, poor diet, lack of physical activity, and excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation and environmental pollutants. In the developing world nearly 20% of cancers are due to infections such as hepatitis B, hepatitis Cand human papillomavirus infection. These factors act, at least partly, by changing the genesof a cell. Typically many genetic changes are required before cancer develops.Approximately 5–10% of cancers are due to inherited genetic defects from a person's parents. Cancer can be detected by certain signs and symptoms or screening tests. It is then typically further investigated by medical imaging and confirmed by biopsy.

http://www.cancerresearchuk.org/health-professional/cancer-statistics/mortality

Total deaths from cancer in the UK alone estimated to 163,444 in 2014 with 46% of death being a result of common cancers

In 2012 a estimate of 14.1 million cases of cancer worldwide with a total of 8.2 million deaths, 33% of cancer cases were linked to the exposure to tobacco.
The four most common cancers occurring worldwide are lung, female breast, bowel and prostate cancer. These four account for around 4 in 10 of all cancers diagnosed worldwide.
Lung cancer is the most common cancer in men worldwide. More than 1 in 10 of all cancers diagnosed in men are lung cancers.
Lung, breast and bowel (including anus), stomach and prostate cancers have been amongst the most commonly diagnosed worldwide since 1975.
Worldwide, almost 32.5 million people diagnosed with cancer within the five years previously were alive at the end of 2012 (estimated).
An estimated 169.3 million years of healthy life were lost globally because of cancer in 2008.
Worldwide there will be 23.6 million new cases of cancer each year by 2030 (estimated).
Incidence rates in the UK are lower than in the European Union in males, but higher in females.
Incidence rates in the UK are lower than in the More Developed Regions of the world in males, but higher in females. For both sexes, rates in the UK are higher than in the Less Developed Regions of the world.

http://www.nhs.uk/Livewell/cancer/Pages/coping-with-cancer-diagnosis.aspx

A cancer diagnosis affects everyone differently, so there are no set rules about how you’re likely to feel, or how you should deal with your emotions.

But, it is common to experience:
sadness
fear about the future
anger
guilt
denial
confusion
stress
anxiety
depression

“Some people get very angry, some are very tearful, most are extremely anxious and worried,” says Fide.

If you think you may be depressed, it’s important to speak to your doctor. Symptoms of depression include lasting feelings of sadness, losing interest in the things you used to enjoy, feeling constantly tired, having difficulty getting to sleep, loss of appetite and feeling that life is not worth living.

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